MEDIA CENTER2018-11-19T17:53:23-06:00

Latest news from Rapha Capital Management & our portfolio companies

AsclepiX Therapeutics
AsclepiX Therapeutics, Inc. Strengthens Board of Directors, Welcomes Steven Altschuler, MD

  • AsclepiX Therapeutics, Inc., a biopharmaceutical company focused on developing novel peptide therapies, including AXT107 for retinal disease and novel peptides for cancer, adds Steven Altschuler, MD to Board of Directors.
  • Dr. Altschuler, the founder and Chairman of the Board of Spark Therapeutics Inc. (NASDAQ: ONCE), brings to AsclepiX a deep knowledge and experience in developing novel therapies for the treatment of retinal disease.
March 25, 2019

AsclepiX Therapeutics
AXT107 Restores Healthy, Non-Leaky Vasculature in the Eye by Inhibiting VEGFR2 and Activating Tie2, the Two Clinically Validated Pathways in Diseases of the Retina

  • AXT107 exhibited a dual mechanism of action as a monotherapy, disrupting a key component of the Vascular Endothelial Growth Factor (VEGF) signaling pathway while also activating the Tie2 pathway that is integral to maintenance of vascular homeostasis.
  • A single monotherapy injection of AXT107 demonstrated in vivo efficacy lasting for many months, suggesting patients may require only 1 to 2 injections per year.
  • To date, AXT107 has demonstrated excellent safety, superior efficacy and longer durability in in vivo models compared to current standard of care treatments.
March 18, 2019

Bellicum Pharmaceuticals, Inc.
Bellicum Reports Safety Results and Promising Activity of Its Controlled CAR-T Candidate BPX-601 in Patients with Advanced Pancreatic Cancer at ESMO-IO
Rimiducid-activated GoCAR-T® resulted in significant expansion and persistence of T cells
Initial evidence of biologic activity and stable disease observed in some patients with single rimiducid dose
BPX-601 was well-tolerated with no CRS or neurotoxicity reported in initial cell-dose escalation
Company to add additional tumor types in Part 2 of study, incorporating standard lymphodepletion and repeat rimiducid dosing
December 14, 2018